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ea0016p564 | Obesity | ECE2008

Leptin decreases and glucose deprivation increases the generation of the soluble leptin receptor (sOb-R) in a cell model

Schaab Michael , Morawe Daniel , Klammt Jurgen , Wilfert Wolfgang , Thiery Joachim , Kratzsch Jurgen

Objective: The soluble leptin receptor (sOb-R) is generated by ectodomain shedding of the membrane-associated Ob-R and may modulate leptin action in metabolic dysregulations. The objective of our study was to investigate whether or not sOb-R generation may be induced by indicators of energy availability or metabolic regulators in a cell model.Material and methods: The four human Ob-R isoforms were cloned, characterized by binding experiments with 125-iod...

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ea0039oc5.3 | Oral Communications 5 | BSPED2015

Dominant negative STAT5B variants in two families with mild GH insensitivity and eczema

Pease-Gevers Evelien , Klammt Jurgen , Andrew Shayne , Kowalczyk Julia , Metherell Lou , Neumann David , Dattani Mehul , Hwa Vivian

Background: Homozygous mutations in STAT5B result in GH insensitivity and immune dysfunction. Heterozygous dominant negative mutations have not been described.Aims and objectives: To assess STAT5B sequence in children selected for a phenotype suggestive of Stat5b deficiency. To further characterize genomic STAT5B variants in two families.Methods: Selection of children from a tertiary Paediatric Endocrine ...

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Endocrine Abstracts

Leptin decreases and glucose deprivation increases the generation of the soluble leptin receptor (sOb-R) in a cell model

Dominant negative STAT5B variants in two families with mild GH insensitivity and eczema

BiosciAbstracts